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P2‐353: SIGNAL COHERENCE IN THE HIPPOCAMPUS IS RELATED TO ITS FUNCTIONAL ISOLATION, PRECLINICAL ALZHEIMER'S DISEASE PATHOLOGY AND MEMORY IN AGING
Author(s) -
Harrison Theresa M.,
Adams Jen.,
Maass Anne,
Du Richard,
Baker Suzanne L.,
Jagust William J.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2760
Subject(s) - precuneus , temporal lobe , hippocampal formation , neuroscience , hippocampus , medicine , resting state fmri , psychology , audiology , functional magnetic resonance imaging , epilepsy
Background: Previous epidemiological studies indicated that the use of anticholinergic (AC) medication is associated with increased risk for cognitive decline or dementia in older adults. Some neuroimaging studies also reported the adverse effects of AC medication on brain atrophy and dysfunction. However, no information is yet available for the association between AC medication use and in vivo Alzheimer’s disease (AD) pathologies such as beta-amyloid deposition and AD-signature neurodegeneration. Therefore, we aimed to examine the association using multimodal neuroimaging in patients with mild cognitive impairment (MCI). Methods: This study included 134 MCI participants of the Korean Brain Aging Study for Early diagnosis and prediction of Alzheimer’s disease (KBASE). All participants underwent comprehensive clinical and neuropsychological assessment, C-Pittsburgh Compound B (PiB) positron emission tomography (PET), F-fluorodeoxyglucose (FDG) PET and brain magnetic resonance imaging. Exposure variable was the use of AC medications during 4 weeks before the assessment visit and participants were classified into AC+ or ACgroup. The list of AC medications was determined according to the literature review. Outcome variables were global PiB standardized uptake value ratio (SUVR), AD-signature region cerebral glucose metabolism (AD-CM), and hippocampal to intracranial volume ratio (HVR, %). Using the analysis of covariance, the mean values of outcome variables were compared between AC+ and ACgroup, after adjusting age, sex, apolipoprotein 34 positivity, clinical dementia rating scale sum of boxes score, total score of geriatric depression scale, and total number of prescribed medications and comorbidities. Results: Of the 134 participants, 55 (41.0 %) participants were taking ACmedications (Table 1). After adjusting potential covariates, the mean global PiB SUVR was higher in AC+ group than that of ACgroup, and both the mean AD-CM and mean HVR of the AC+ group were lower than those of ACgroup (Table 2). Conclusions: The findings suggest that AC medication use may contribute to in vivo AD pathologies, such as amyloid deposition and AD-type neurodegenerations, although further longitudinal studies are needed to confirm the relationship. P2-353 SIGNAL COHERENCE IN THE HIPPOCAMPUS IS RELATED TO ITS FUNCTIONAL ISOLATION, PRECLINICAL ALZHEIMER’SDISEASEPATHOLOGYAND MEMORY IN AGING Theresa M. Harrison, Jenna N. Adams, Anne Maass, Richard Du, Suzanne L. Baker, William J. Jagust, University of California Berkeley, Berkeley, CA, USA; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Lawrence Berkeley National Laboratory, Berkeley, CA, USA; University of California, Berkeley, Berkeley, CA, USA. Contact e-mail: theresamaria@gmail.com