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P2‐352: ASSOCIATION OF ANTICHOLINERGIC MEDICATION USE WITH IN VIVO ALZHEIMER'S DISEASE PATHOLOGIES
Author(s) -
Lee Jun Ho,
Byun Min Soo,
Yi Dahyun,
Jeon So Yeon,
Jung Gijung,
Lee Han Na,
Sohn Bo Kyung,
Lee Jun-Young,
Ryu Seung-Ho,
Lee Dong Woo,
Lee Dong Young
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2759
Subject(s) - dementia , pittsburgh compound b , medicine , clinical dementia rating , neuroimaging , standardized uptake value , cognitive decline , alzheimer's disease , positron emission tomography , disease , psychiatry , nuclear medicine
Background: Vascular disease pathology is a common comorbidity in multiple degenerative diseases and measured as white matter hyperintensities (WMH) on T2 images. The origin and specific role of WMH in different diseases is incompletely understood. In this work, we compared WMH burden in Alzheimers (AD) and Parkinsons disease (PD). We tested association with cerebral blood flow (CBF) as a marker of vascular insufficiency and mean diffusivity (MD) in white matter as a marker of axonal/myelin rarefaction. We also evaluated the association of WMH burden, CBF, and MD with the administered cognitive battery. Methods: 114 (Table 1) individuals underwent FLAIR, pCASL, and DTI MRI. Subjects were recruited at the local ADRC and Udall Center and analyzed separately. Lobar WMH burden was calculated and subdivided into lobar periventricular (PVH) and deep (DH) WMH. We tested the hypothesis that PVH and DH burden were associated with MD and CBF respectively in both diseases. Furthermore, we tested association of all cognitive tests (MoCA, MiNT, CATFLU, CRAFT) that were available for all subjects with hypothesized lobar WMH burden, CBF, and MD. Results: We show that AD subjects have a significantly higher PVH burden than NC especially in the frontal and parietal lobes as well as a higher frontal DH burden (Figure 1). No association was detected between PVH and MD or between DH and CBF. Low CATFLU scores were significantly associated with higher temporo-frontal CBF and temporal MD (Figure 2). Low MoCA scores were associated with high parieto-temporal MD. For PD subjects, no significant difference in WMH burden was observed compared to NC. WMH burden was associated with MD in PD. No association was observed with lobar CBF. Temporal WMH was associated with MoCA, CATFLU and MiNT in PD (Figure 3). All tests were adjusted for age and sex. Conclusions: WMH burden is higher in AD than PD.CBF was associated with cognitive symptoms in AD not PD. While commonly associated with executive functioning, we found associations of WMH andMDwith cognition only in PD. Vascular pathology manifests differently in different degenerative diseases indicating that it may play a more mechanistic role in AD than just being a comorbidity.