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P2‐349: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY OF HEALTHY AGING AND ALZHEIMER'S DISEASE
Author(s) -
Mecca Adam P.,
Chen Ming-Kai,
Godek Tyler A.,
Harris Joanna E.,
Bartlett Hugh H.,
Toyonaga Takuya,
Naganawa Mika,
Salardini Arash,
Arnsten Amy F.T.,
Nabulsi Nabeel B.,
Lim Keunpoong,
Najafzadeh Soheila,
Ropchan Jim R.,
Huang Yiyun,
Carson Richard E.,
Strittmatter Stephen M.,
Dyck Christopher H.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2756
Subject(s) - neuroscience , cingulum (brain) , metabotropic glutamate receptor 5 , precuneus , entorhinal cortex , hippocampus , cortex (anatomy) , psychology , medicine , glutamate receptor , metabotropic glutamate receptor , magnetic resonance imaging , functional magnetic resonance imaging , receptor , radiology , white matter , fractional anisotropy
This analysis revealed that BMI was related to hypermetabolism only in females (Figure 2-top), whereas both sexes presented atrophy in relation to BMI. Conclusions: Obesity is related to both hypermetabolism and brain atrophy in the same widespread cortical regions in healthy elderly. These findings could be explained by a neuroinflammation effect produced by the obesity in the brain. This neuroinflammatory response to obesity would be greater in females than males.