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P2‐341: AGE AND APOE GENOTYPE INTERACTION ON WHITE MATTER MYELIN IN COGNITIVELY NORMAL MIDDLE‐AGED PARTICIPANTS
Author(s) -
Operto Grégory,
Molinuevo Jose Luis,
Falcon Carles,
Cacciaglia Raffaele,
Brugulat-Serrat Anna,
Grau-Rivera Oriol,
Suárez-Calvet Marc,
Gispert Juan Domingo
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2748
Subject(s) - apolipoprotein e , myelin , white matter , psychology , population , genotype , audiology , medicine , neuroscience , disease , magnetic resonance imaging , biology , genetics , central nervous system , radiology , gene , environmental health
risk for AD. Methods: 205 older cognitively intact individuals with subjective memory complaints from the INSIGHT pre-AD cohortwho underwent resting state functional magnetic resonance imaging (rs-fMRI) scan were included (124 females, mean age: 75.7 6 3.4) (Dubois et al., 2018). Individual functional connectivity matrices Results: PLSC analysis identifiedone significant component of co-variation between the two sets (p<.006), that we named bio-neural mode. In particular, five core plasma biomarkers (figure1) and 190 connectomes (figure2) were significant (bootstrap ratios Sj1.96j); t-tau protein showed a trend towards significance (bootstrap ratio1⁄4 1.64). Conclusions: A strong association between network dynamics and core pathophysiological blood biomarkers was detected. An integrative connectomics approach relating fluid biomarkers to functional dynamics may represent outcomes useful both for drug development and clinical practice (Hampel et al., 2018b). Further longitudinal studies may help at identifying whether brain longitudinal individuals’ changes are related to blood-based biomarkers in the AD continuum. P2-340 LASTING CONSEQUENCES OF CONCUSSION: BRAIN FINDINGS FROM THE BALTIMORE LONGITUDINAL STUDY OFAGING