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P2‐335: DIFFERENCE ANALYSIS OF DWI AND CORTICAL THICKNESS IN THE ALZHEIMER'S DISEASE CONNECTOME PROJECT
Author(s) -
Adluru Nagesh,
Nair Veena A.,
Oh Jennifer M.,
Hwang Gyujoon,
Prabhakaran Vivek,
Li Shi-Jiang,
Alexander Andrew L.,
Bendlin Barbara B.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2742
Subject(s) - diffusion mri , pairwise comparison , fractional anisotropy , dementia , human connectome project , white matter , correlation , cognitive impairment , psychology , disease , pattern recognition (psychology) , statistics , medicine , mathematics , nuclear medicine , magnetic resonance imaging , pathology , neuroscience , radiology , cognitive psychology , functional connectivity , geometry
LOAD had lower thickness than EOAD in the precentral gyrus and superior-temporal gyrus (Fig. 2). In contrast to GM-thickness, GMFW increases appeared early at the pre-dementia stage (LOMCI>EOMCI). EOAD had greater GM-FW increases in the parietal/ precuneus and middle-temporal regions than LOAD (Fig. 3). Lastly, parietal GM-FW increases contributed to global cognitive impairment in MCI while parietal and temporal WM abnormalities and GM thinning related to lower MoCA in dementia (Table 1). Conclusions: Our study revealed differential patterns of GM and WM macro/microstructural changes in earlyand late-onset AD and MCI. Findings suggested that GM microstructural changes appeared earlier than cortical thinning and were better associated with cognitive decline. The combined WM and GM microstructural assays could help differential diagnosis and early detection in preclinical and prodromal stages of neurodegeneration.