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P2‐299: EFFECT OF APOLIPOPROTEIN E ε4 ALLELE ON PROGRESSION RATE OF COGNITIVE DECLINE IN PRODROMAL AND MILD ALZHEIMER'S DISEASE
Author(s) -
Suzuki Kazushi,
Ihara Ryoko,
Ikeuchi Takeshi,
Iwata Atsushi,
Iwatsubo Takeshi
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2706
Subject(s) - apolipoprotein e , medicine , cognitive decline , clinical dementia rating , allele , dementia , population , oncology , alzheimer's disease , gastroenterology , psychology , alzheimer's disease neuroimaging initiative , disease , biology , genetics , gene , environmental health
years, each subject received an annual evaluation that included a clinical interview and an assessment of their cognitive status as measured by a Clinical Dementia Rating – Sum of Boxes (CDR-SOB) score. Linear mixed-effects models were used to test for associations between each factor and the CDR-SOB score over time. These analyses were then repeated in a multivariate linear mixed-effects model after adjusting the covariates. Results: Age, DM, and baseline severity were identified as potential covariates that influence clinical progression; however, a subject’s muscle profile was not found to predict dementia progression. Conclusions: We expect that early screening and intervention, as well as new drugs with mechanisms of action similar to those of antidiabetic medications, will help patients with dementia maintain their clinical status.