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P2‐275: CLINICAL CHARACTERISTICS OF PATHOLOGICALLY CONFIRMED EARLY ONSET DEMENTIA WITH LEWY BODIES
Author(s) -
Hameed Shahul,
Ting Simon,
Kandiah Nagaendran,
Lyn Ng Adeline Su,
Ng Kok Pin,
Chen Celeste,
Li Huihua,
Tan Eng King
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2682
Subject(s) - dementia with lewy bodies , apathy , dementia , age of onset , neuropsychology , pediatrics , psychology , psychiatry , neurology , medicine , disease , cognition , audiology
muscle mass profiles and their relationship to dementia trajectories have not been extensively investigated. We investigated factors which affect the rate of clinical decline and the usefulness of muscle profiles for predicting the clinical outcomes of dementia patients with Alzheimer’s dementia (AD). Methods: Sixty-nine subjects with probable AD, but without muscle weakness, were included this study. Variables including age, years of education, hypertension, diabetes mellitus, lacunar infarcts, baseline cognition, muscle mass, and strength were assessed during the initial visit of each subject. Over a period of three years, each subject received an annual evaluation that included a clinical interview and an assessment of their cognitive status as measured by a Clinical Dementia Rating – Sum of Boxes (CDR-SOB) score. Linear mixed-effects models were used to test for associations between each factor and the CDR-SOB score over time. These analyses were then repeated in a multivariate linear mixed-effects model after adjusting the covariates. Results: Age, DM, and baseline severity were identified as potential covariates that influence clinical progression; however, a subject’s muscle profile was not found to predict dementia progression. Conclusions: We expect that early screening and intervention, as well as new drugs with mechanisms of action similar to those of antidiabetic medications, will help patients with dementia maintain their clinical status.