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P2‐274: MUSCLE PROFILE AND PROGRESSION OF ALZHEIMER'S DEMENTIA: PREDICTORS OF POOR CLINICAL OUTCOME AND ROLE OF MUSCLE PROFILE, A 3‐YEAR LONGITUDINAL STUDY
Author(s) -
Wook Kim Dong,
Moon Yeonsil
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2681
Subject(s) - dementia , clinical dementia rating , medicine , muscle weakness , affect (linguistics) , multivariate analysis , diabetes mellitus , longitudinal study , physical therapy , psychology , disease , pathology , endocrinology , communication
study compared AA and Caucasian symptomatic former National Football League (NFL) players on neurobehavioral outcomes, structural MRI indices, and cerebrospinal fluid (CSF) concentrations of total tau (t-tau), phosphorylated tau (p1⁄4tau), and Ab. Methods: Ninety-five symptomatic former NFL players (ages 40-69; n1⁄442 AA, n1⁄453 Caucasians) underwent neurobehavioral testing, structural MRI, and lumbar puncture to quantify CSF t-tau, and p-tau181, Ab1-42using immunoassays. Principal component analysis generated behavior/mood, psychomotor speed/executive function, and verbal and visual memory factor scores. FreeSurfer derived volumetric output. The cumulative head impact index (CHII) estimated RHI. Linear regressions examined the effect of AA on each neurobehavioral, structural MRI, and CSF variable, controlling for age, BMI, and the CHII (and intracranial volume for structural MRI, and education for neurobehavioral analyses). Sample sizes varied due to missing data (n1⁄484-86). Results: Compared to Caucasians, AA had a higher BMI (p1⁄40.017) and were three years younger (p1⁄40.025). There were no differences in education or years of play. Compared to Caucasians, AA exhibited worse psychomotor speed/executive function (t1⁄4-4.33, p<0.001), had greater white matter hypointensity burden (t1⁄42.96, p1⁄40.004), and smaller volume of the right hippocampus (t1⁄42.97, p1⁄40.004), cortical white matter (t1⁄4-2.69, p1⁄40.009), and total gray matter (t1⁄44.51, p<0.001). AA had a higher p-tau181/t-tau ratio (t1⁄4 3.09, p 1⁄4 0.003) and lower Ab1-42(t1⁄4-2.48, p1⁄40.015). Conclusions: In this sample of former NFL players, AA racewas associated with worse executive function, greater structural brain alterations, and lower Ab1-42concentrations and higherp-tau181/t-tau ratio levels. These findings coincide with the extant literature on the differential race effects on neurobehavioral and neurologic outcomes in the general population. AA make up a large proportion of the football population, particularly at the professional level, and studies examining neurologic outcomes in this population should account for race.