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P2‐255: ULTRASENSITIVE EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE USING CARBON NANOTUBE‐BASED BIOSENSOR ARRAYS
Author(s) -
Begum Aynun N.,
Alam Maksudul M.,
Ray Anamika,
Sampathkumaran Uma,
Tang Yifan,
Madakashira Harini,
Johnston Anthonie,
Kim Elizabeth,
Villanueva Monica,
Mushfiq Mohammad
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2662
Subject(s) - senile plaques , tau protein , biomarker , carbon nanotube , microelectronics , biosensor , medicine , disease , alzheimer's disease , amyloid beta , nanotechnology , materials science , neuroscience , chemistry , pathology , biology , biochemistry
speech and pause segment durations, pause count and rate. We compared the patients’ prosodic markers with those of 37 healthy controls (HC) and two cognitive control groups with either bvFTD (n1⁄490) or naPPA (n1⁄423) and no motor disease. We associated prosodic markers in ALS with clinical measures of severity (FVC – Forced Vital Capacity, ALSFRS – ALS Functional Rating Scale, ECAS– Edinburgh Cognitive and Behavioral ALS Screen). Results: The ALS+cog group had a prosodic pattern distinct from pure motor ALS, including a restricted f0 range (mean 3.761.6 ST vs. 5.062.0 ST respectively, p1⁄40.03, controlled for demographic variation); increased pause rate (mean 46.2616.9 vs. 36.1616.5 ppm, p1⁄40.04) and reduced total speech time (mean 25.5611.6 vs. 42.5616.1 sec, p1⁄40.003). ALS+cog resembled the bvFTD and naPPA groups in all of these prosodic markers, except for pause rate, where naPPA had a higher rate. Within the entire ALS cohort total speech time was associated with ECAS total score and ALS-specific subscore (r1⁄40.3, p1⁄40.04 for both), however, we found no correlation between prosodic markers and severity of motor impairment. Conclusions: Automated speech analysis yields sensitive prosodic markers that distinguish ALS patients with cognitive impairment. P2-255 ULTRASENSITIVE EARLY DIAGNOSIS OF ALZHEIMER’S DISEASE USING CARBON NANOTUBE-BASED BIOSENSOR ARRAYS