Premium
P2‐238: SEASONAL EFFECTS ON CEREBROSPINAL FLUID AMYLOID BETA 42 PEPTIDE LEVELS IN A COGNITIVELY NORMAL ELDERLY COHORT FROM NEW YORK CITY
Author(s) -
Can Hande,
Cavedoni Bianca,
Corredor Ingrid,
Miller Margo D.,
Parekh Ankit,
Bubu Omonigho M.,
Rapoport David M.,
Ayappa Indu,
Varga Andrew W.,
Osorio Ricardo S.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2645
Subject(s) - cohort , circadian rhythm , medicine , cerebrospinal fluid , confounding , dementia , cohort study , alzheimer's disease , physiology , demography , endocrinology , disease , sociology
terminal (tau 368 and K9JA). Results: Results show that individual antibodies selectively bind to specific tauopathies whilst staining negative to others, confirming a distinct fibril organisation for each tauopathy. Comparing all results to the gold standard for staining of tau pathological inclusions (using AT8 antibody), N-terminal antibodies only stained PiD inclusions and partly GGT. Antibodies targeting the proline rich domain of tau, positively stained the pathological inclusions present in all tauopathies. Finally, C-terminal antibodies positively bound to tangles and to a lesser extent to astrocytic inclusions present in CBD and PSP. Conclusions: Here, we report the potential of several tau antibodies to selectively bind to specific forms of tauopathy.