Premium
P2‐237: IMMUNOHISTOCHEMICAL PROFILING OF PRIMARY TAUOPATHIES
Author(s) -
Foiani Martha S.,
Jackson-Morgan Taniesha,
Cicognola Claudia,
Ermann Natalia,
Heslegrave Amanda J.,
Ye Keqiang,
Kornhuber Johannes,
Lewczuk Piotr,
Zetterberg Henrik,
Höglund Kina,
Rohrer Jonathan D.,
Lashley Tammaryn
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2644
Subject(s) - tauopathy , progressive supranuclear palsy , corticobasal degeneration , tau protein , pathology , pick's disease , antibody , biology , immunohistochemistry , neurodegeneration , alzheimer's disease , dementia , medicine , disease , immunology
were associated with a worse frontal/executive function (b1⁄4 -0.210; p1⁄40.035 and b1⁄40.269; p1⁄40.007, respectively). Lower M10 were also associated with more disability (b1⁄4-0.255; p1⁄40.004). From subset of 39 participants, longer cellular period was associated with worse frontal/executive function and more disability (pearson r1⁄4-0.378; p1⁄40.025 and r1⁄40.369; p1⁄40.032, respectively). However, neither behavioral nor cellular circadian rhythm parameter was associated with cortical amyloid burden. Conclusions: Taken together, our results suggest that behavioral and cellular circadian rhythms are associated with cognition and disability, but not with cortical amyloid burden in patient with mild to moderate cognitive decline.