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P2‐236: THE KYNURENINE PATHWAY AND COGNITIVE FUNCTIONING: RESULTS FROM THE MAASTRICHT STUDY
Author(s) -
Bakker Lieke,
Eussen Simone J.P.M.,
Boxtel Martin P.J.,
Schram Miranda T.,
Stehouwer Coen D.A.,
Kallen Carla J.H.,
Schaper Nicolaas C.,
Dagnelie Pieter,
Greevenbroek Marleen M.J.,
Wesselius Anke,
Midttun Øivind,
Ueland Per M.,
Verhey Frans R.J.,
Ramakers Inez H.G.B.,
Koehler Sebastian
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2643
Subject(s) - kynurenine , xanthurenic acid , quinolinic acid , kynurenine pathway , kynurenic acid , population , cognition , medicine , psychology , endocrinology , biology , psychiatry , biochemistry , tryptophan , environmental health , amino acid , nmda receptor , receptor
were associated with a worse frontal/executive function (b1⁄4 -0.210; p1⁄40.035 and b1⁄40.269; p1⁄40.007, respectively). Lower M10 were also associated with more disability (b1⁄4-0.255; p1⁄40.004). From subset of 39 participants, longer cellular period was associated with worse frontal/executive function and more disability (pearson r1⁄4-0.378; p1⁄40.025 and r1⁄40.369; p1⁄40.032, respectively). However, neither behavioral nor cellular circadian rhythm parameter was associated with cortical amyloid burden. Conclusions: Taken together, our results suggest that behavioral and cellular circadian rhythms are associated with cognition and disability, but not with cortical amyloid burden in patient with mild to moderate cognitive decline.