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P2‐235: BEHAVIORAL AND CELLULAR CIRCADIAN RHYTHMS ARE ASSOCIATED WITH COGNITION AND DISABILITY, BUT NOT WITH CORTICAL AMYLOID BURDEN IN PATIENT WITH COGNITIVE IMPAIRMENT
Author(s) -
Roh Hyun Woong,
Choi Jung-gu,
Youn Kyoung Sun,
Yoon Dukyong,
Seo Sang Won,
Kim Eun Young,
Son Sang Joon,
Hong Chang Hyung
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2642
Subject(s) - circadian rhythm , actigraphy , dementia , psychology , neurocognitive , alzheimer's disease , neuroscience , clinical dementia rating , medicine , cognition , audiology , disease
sensitive was Vigilance-index (1.0) then total-Tau (0.5) and the rest lower, least for the combination of Csf parameters (0.09) (Tab1). The actual number of pathologic values with the best correlation to pathological MMSE scores, both at baseline and the increased numbers at follow-up was for Vigilance-index (Fig. 2). Conclusions: Vigilance-index best reflects cognitive decline measured by the MMSE of examined parameters, due to its measure of the cholinergic deficit which seems to occur early in suspected dementia diseases such as Alzheimer‘s and Lewy body dementia. Therefore, the Vigilance-index analyze offers opportunities to start treatment with Acetylcholinesterase inhibitors when only mild cognitive impairment. The Vigilance-index can also be used to identify other medical treatments with unwanted central anticholinergic side effects leading to secondary cognitive symptoms.