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P2‐233: NOVEL HIGHLY‐SENSITIVE METHOD FOR THE IDENTIFICATION OF ALZHEIMER'S DISEASES WITH HUMAN BLOOD
Author(s) -
Shin Kyeong-Sik,
Kim Miso,
Heo Youhee,
Kang Ji Yoon
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2640
Subject(s) - microvesicles , monomer , electrical impedance , identification (biology) , signal (programming language) , extraction (chemistry) , materials science , electrode , biological system , chemistry , biophysics , biomedical engineering , computer science , chromatography , biology , medicine , microrna , biochemistry , physics , composite material , quantum mechanics , gene , programming language , polymer , botany
It is also possible that putative TBI biomarkers may have implications for the detection of neurodegenerative diseases including CTE. Methods: A three-tone auditory oddball task using an eight electrodes COGNISION rig was used in 137 participants from a memory disorders clinic with and without a history of TBI based on chart review and self-report. Results: Both P50 standard and target latencies were significantly different between the TBI and non TBI groups (p< 0.005 and p< 0.05). Both P50 target and standard latencies showed longer latencies in the TBI group. By performing two logistic regressions, we also found that both P50 latencies are significant predictors for the presence or absence of TBI. Conclusions: P50 has been previously used to examine the ability of the brain to inhibit irrelevant sensory inputs, reflecting a pre-attentional inhibitory mechanism that could be protecting higher order cognitive functions. Our results, showing significant greater latency, are consistent with the idea that older individuals with TBI history and a memory disorder have impaired pre-attentional inhibitory control. This exploratory finding may be useful in evaluating markers of neurodegeneration in individuals at risk for chronic traumatic encephalopathy and other neurodegenerative conditions related to repetitive TBI.