P2‐198: PM2.5 INDUCES NEUROINFLAMMATION IN GLIAL CELLS: ASSOCIATION WITH TPA/PAI‐1 SYSTEM

microenvironment was associated with increased proand antiinflammatory proteins in AD, while immunotherapy appears to trigger an anti-inflammatory environment. Conclusions: Our findings suggest that as Ab appears during the ageing process, the homeostatic Iba1 and P2RY12 –positive microglia respond to Ab, but this response is absent in AD, as ramified microglia decrease, implying that baseline motility is affected. Ab-immunisation promoted increased Iba1 and P2RY12 expression, likely reflecting increased baseline microglial motility but without restoring the profile observed in controls.