Premium
P2‐198: PM2.5 INDUCES NEUROINFLAMMATION IN GLIAL CELLS: ASSOCIATION WITH TPA/PAI‐1 SYSTEM
Author(s) -
Kim Ryeung-Eun,
Han Seol-Heui,
Kwon Kyoung JA.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2605
Subject(s) - neurotoxicity , neuroinflammation , nitric oxide , chemistry , reactive oxygen species , microglia , astrocyte , inflammation , proinflammatory cytokine , pharmacology , nitric oxide synthase , microbiology and biotechnology , immunology , biology , biochemistry , endocrinology , central nervous system , toxicity , organic chemistry
microenvironment was associated with increased proand antiinflammatory proteins in AD, while immunotherapy appears to trigger an anti-inflammatory environment. Conclusions: Our findings suggest that as Ab appears during the ageing process, the homeostatic Iba1 and P2RY12 –positive microglia respond to Ab, but this response is absent in AD, as ramified microglia decrease, implying that baseline motility is affected. Ab-immunisation promoted increased Iba1 and P2RY12 expression, likely reflecting increased baseline microglial motility but without restoring the profile observed in controls.