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P2‐182: DEFECTIVE MIRNA‐223‐MEDIATED REGULATION OF NLRP3 INFLAMMASOME ACTIVATION IN ALZHEIMER'S DISEASE
Author(s) -
La Rosa Francesca,
Saresella Marina,
Piancone Federica,
Marventano Ivana,
Mancuso Roberta,
Hernis Ambra,
Fenoglio Chiara,
Galimberti Daniela,
Scarpini Elio,
Clerici Mario
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2589
Subject(s) - inflammasome , caspase 1 , peripheral blood mononuclear cell , inflammation , microrna , aim2 , immunology , immune system , interleukin , biology , cytokine , gene , genetics , in vitro
null background. Results: Hyperphosphorylation of tau was detected by Western blots only on a sub-acute basis in the hippocampus, but neuronal accumulation of phospho-tau was sustained in the chronic phase, in parallel to prolonged astrogliosis, decreased neural and synaptic markers, and cognitive and locomotor impairment. Conclusions: CCI induces Alzheimer-like brain alterations which include intraneuronal accumulation of phospho-tau and astrogliosis, along with neurobehavioral impairment in adult mice expressing only non-mutated human tau.