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P2‐109: CSF CHOLINERGIC INDEX, A NEW BIOMEASURE OF TREATMENT EFFECT IN PATIENTS WITH ALZHEIMER'S DISEASE
Author(s) -
Karami Azadeh,
Eriksdotter Maria,
Kadir Ahmadul,
Almkvist Ove,
Nordberg Agneta K.,
Darreh-Shori Taher
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2516
Subject(s) - galantamine , acetylcholinesterase , cholinergic , choline acetyltransferase , acetylcholine , cholinesterase , medicine , placebo , aché , cholinergic neuron , endocrinology , donepezil , psychology , pharmacology , dementia , chemistry , disease , pathology , enzyme , biochemistry , alternative medicine
CSF from head CT using probabilistic, atlas-based classification. Feasibility and utility were evaluated by comparing MRI-only to CT-only segmentations in 10 older adults [mean (m) 6 standard deviation (s) of age 1⁄4 65 6 7 yrs; 5 females] from whom both MRI and CT scans were acquired within an eight-week period. Segmentation similarity was quantified using the Dice coefficient (DC), a robust measure of inter-modality tissue classification agreement. Results: Comparison of MRI vs. CT segmentations yielded normally-distributed DCs [m 6 s across participants: 85.5% 6 4.6% (WM), 86.7% 6 5.6% (GM) and 91.3% 6 2.8% (CSF)], indicating satisfactory ability to calculate brain volumetrics from the CT scans of the participants, relative to MRI measurements. For this sample, bootstrapping suggests that the tissue classification method is sufficiently sensitive to estimate WM, GM and CSF volumes withinw5%,w4% andw3% of their MRI-based values, respectively. Compared to MRI, volumes computed from CT displayed no evidence of systematic overor under-estimation [t (9)1⁄4 0.89, p> 0.80]. Conclusions: Our contribution broadens the ability to integrate CT imaging findings with other research on brain aging in health and disease, and complements other methodologies for the study of brain volumetrics in neurodegenerative diseases, including AD.