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P2‐100: SINGLE‐CELL TRANSCRIPTOMIC PROFILING OF TREM2 DEFICIENT MICROGLIA IN RESPONSE TO INTRACRANIAL INFUSION OF Aβ PARTICLES
Author(s) -
Nam Kyong Nyon,
Fitz Nicholas F.,
Biedrzycki Richard J.,
Playso Brittany E.,
Wolfe Cody M.,
Lefterov Iliya,
Koldamova Radosveta
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2507
Subject(s) - trem2 , microglia , apolipoprotein e , transcriptome , biology , immune system , phagocytosis , allele , cell , receptor , microbiology and biotechnology , immunology , inflammation , gene , medicine , gene expression , genetics , disease
hippocampal and cortical areas. Graph measures demonstrated a consistent reorganization in the brain metabolic network indexed by lower density, reduced global efficiency, assortativity, small-worldness, degree and clustering coefficient. Conclusions: Our [F]FDG PET regional analysis demonstrated a hypometabolism in several brain regions, including the hippocampus during sepsis. Additionally, metabolic network is hyposynchronic in the CLP group and graph measures revealed that brain regions, including the hippocampus, are exchanging information less efficiently. These findings indicate that sepsis causes glucose abnormalities similar to those observed in AD, which reinforces sepsis as a potential long-term risk factor for developing AD. PROFILING OF TREM2 DEFICIENT MICROGLIA IN RESPONSE TO P2-100 SINGLE-CELLTRANSCRIPTOMIC