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P2‐089: INDEPENDENT OF CSF AMYLOID/TAU LEVELS, HIGHER (NORMAL) DIASTOLIC BLOOD PRESSURE IN COGNITIVELY HEALTHY SENIORS ASSOCIATES WITH BETTER (NORMAL) EXECUTIVE FUNCTION AND WITH LESSER (NORMAL) MEMORY
Author(s) -
Harrington Michael G.,
Siddarth Prabha,
Miller Karen J.,
Sweeney Melanie D.,
Zlokovic Berislav V.,
Chui Helena C.,
Fonteh Alfred N.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2496
Subject(s) - blood pressure , cardiology , stroop effect , medicine , population , pulse pressure , dementia , cognition , audiology , psychology , disease , psychiatry , environmental health
AD and modulated by the use of statin.Methods:12-weeks-old female mice from the hAPP-J20 line were stereotactically administered collagenase (0.8mU/mL) to induce cortical lesion. CMBmice received Atorvastatin (At) (5mg/kg/day) over the followup period. At six weeks post-surgery, we performed a multimodal assessment, including cognitive performances (spontaneous activity, anxiety, working, visuo-spatial and recognition memory), cerebral volume and metabolism by MRI and fluorodeoxyglucose (FDG)-PET. Results: At six weeks post-surgery, CMB-mice showed a lower level of anxiety, restored by the use of At (31% of total time spent in open arms in CMB-mice vs 13% in Shammice vs 16% in CMB-AT-mice). A decline in visuo-spatial and recognition memory was also observed in CMB-mice, but this difference was not significant, Sham-mice showed already a severe impairment in visuo-spatial memory. The spontaneous activity and the working memory were not disturbed. The volume and metabolism in the cortex and the hippocampus were similar in the three groups. Conclusions: In our female transgenic model, CMB early affected the non cognitive performance, which was sensitive to a pharmalogical modulation by At.