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P2‐073: ROLE OF GIRK CHANNELS IN LONG‐TERM POTENTIATION OF SYNAPTIC INHIBITION IN AN IN VIVO MODEL OF EARLY AMYLOID‐β PATHOLOGY
Author(s) -
Sanchez-Rodriguez Irene,
Gruat Agnès,
Delgado-Garcia Jose Maria,
Jimenez-Diaz Lydia,
Navarro-Lopez Juan D.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2480
Subject(s) - g protein coupled inwardly rectifying potassium channel , long term potentiation , neuroscience , inhibitory postsynaptic potential , excitatory postsynaptic potential , postsynaptic potential , hippocampal formation , synaptic plasticity , neurotransmission , biology , chemistry , microbiology and biotechnology , signal transduction , g protein , receptor , biochemistry
to 0.68 (accuracy). Classification was generally better with CSF measurement, MCI patients, and when including ApoE as a covariate. This may be explained by greater CSF amyloid prominence in pre-clinical or MCI AD compared to amyloid accumulation in the brain. Conclusions:This preliminary study demonstrates the ability for HBCP models to accurately classify amyloid positivity with noninvasive cognitive assessment responses.