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P2‐044: THE EFFECT OF STANDARDIZED EXTRACT OF ASIAN HERB IM01 ON CONDITIONED FEAR MEMORY DEFICIT OF 3XTG‐AD MICE
Author(s) -
Pairojana Tanita,
Phasuk Sarayut,
Huang Shun-Ping,
Tantisira Mayuree,
Chompoopong Supin,
Pakaprot Narawut,
Liu Ingrid Y.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1266
Subject(s) - neuroprotection , genetically modified mouse , medicine , microglia , nitric oxide , pathogenesis , pharmacology , memory improvement , hippocampus , memory impairment , transgene , inflammation , chemistry , psychiatry , biochemistry , cognition , gene
were evaluated through open field test (OFT), elevated plus maze test (EPMT), novel object recognition test (NORT). Results: The comparison was made between the groups and the analysis showed that the exploration and memory in DC decreased significantly in the OFT, EPMT, NORT, whereas a significant improvement was observed in the test groups treated with medicinal plants. However, S+C group results in all the behavioral tests were analogous to HC but on the other hand showed significant improvement when compared with the behavioral tests of S, C and DC groups. Conclusions: Therefore, it has been concluded that herbs as saffron and chamomile with strong acetylcholinesterase and butyrylcholinesterase activities can bring betterment in the age-related brain dysfunctions as dementia and despair that are hall marks of AD. These indigenous herbs may become a prospective treatment modality in people with AD.