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P2‐026: CHANGES IN ADIPOSITY AND CSF BIOMARKERS FOLLOWING A MODIFIED MEDITERRANEAN KETOGENIC DIET
Author(s) -
Brinkley Tina E.,
Register Thomas C.,
Zetterberg Henrik,
Dahl Deborah,
Neth Bryan J.,
Craft Suzanne
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1248
Subject(s) - ketogenic diet , medicine , cerebrospinal fluid , endocrinology , mediterranean diet , lumbar , gastroenterology , epilepsy , surgery , psychiatry
(p1⁄40.02) and Omega-6, LA derived 9,10-DiHOME/9,10-EpOME (p1⁄40.05.) ratios (Figures 1, 2). Higher 19,20-DiHDPA/19,20-EpDPE, an omega-3 derived diol/epoxide ratio from DHA, showed a significant positive association with Trails-B (p 1⁄4 0.04) (Figure 3). There was no association with DHA or single DHA derived oxylipins or diols and Trails-B.We have previously reported a protective association with DHA P450 derived oxylipin 16,17-EpDPE and WMH (p1⁄40.005). Conclusions: MRI markers did not correlate with parent fatty acid compounds and no parent PUFA correlated with Trails-B, suggesting their derivatives may be the key mediators in brain changes. Soluble Epoxide Hydrolase-derived oxylipin products may negatively impact vascular cognitive health, therefore a better understanding of the relationships between oxylipins and diols is warranted.