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P2‐025: PRODUCTS FROM SOLUBLE EPOXIDE HYDROLASE DERIVED OMEGA‐6 AND OMEGA‐3 OXYLIPINS ARE ASSOCIATED WITH INCREASED WHITE MATTER HYPERINTENSITY AND POORER PERFORMANCE ON TRAILS‐B IN A COHORT OF COGNITIVELY NORMAL, HYPERTENSIVE YOUNG‐OLD
Author(s) -
Shinto Lynne,
Lahna David,
Dodge Hiroko H.,
Hagen Kirsten,
Koop Dennis,
Quinn Joseph F.,
Kaye Jeffrey A.,
Silbert Lisa C.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1247
Subject(s) - epoxide hydrolase 2 , oxylipin , docosahexaenoic acid , eicosapentaenoic acid , hyperintensity , arachidonic acid , polyunsaturated fatty acid , fish oil , chemistry , medicine , epoxyeicosatrienoic acid , white matter , biochemistry , endocrinology , fatty acid , biology , magnetic resonance imaging , enzyme , fishery , fish <actinopterygii> , radiology
have reduced the chance of incurring post-LP complications or symptoms such as low-pressure headache, patients generally remain anxious about the procedure. This functions as a barrier to patient recruitment into studies with a voluntary LP component. Methods: To better understand patient’s attitudes towards the LP procedure in research, we devised a prepost-LP survey to assess anticipatory anxiety, experienced pain associated with the procedure, and prospective anxiety about receiving a future LP. Patients were recruited from two ongoing studies requiring an LP procedure performed by the same trained clinicians using 24G or 22G Sprotte needles. Results: A total of 48 subjects undergoing an LP procedure completed the survey, 17 of whom repeated the survey a second time following a second longitudinal LP administered 8-16 weeks after the first LP. Results indicate that the level of pre-LP anxiety is not related to how painful they actually found the procedure to be, although those who experienced greater pain during the procedure were more anxious about the thought of a future LP. Longitudinally, there were no significant differences in pain ratings between the first and second LPs, although there was a significant decrease in the level of pre-LP anticipatory anxiety prior to the second LP procedure. Conclusions: The results from this survey demonstrate that patients are less anxious about undergoing a lumbar puncture if they have already had one previously and that the less painful the initial LP is, the less anxious the patient will be regarding future LPs. It is important for clinicians to understand patient anxiety associated with undergoing an LP, especially in the context of research and novel drug delivery that may involve routine LP procedures. Educational strategies during recruitment may be helpful in decreasing anticipatory anxiety and increasing interest in LP research participation.