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P2‐016: EXPLORING THE EFFECT OF SOUVENAID ON CEREBRAL GLUCOSE METABOLISM IN EARLY ALZHEIMER'S DISEASE
Author(s) -
Briels Casper T.,
Scheltens Nienke M.E.,
Yaqub Maqsood M.,
Barkhof Frederik,
Boellaard Ronald,
Flier Wiesje M.,
Schwarte Lothar A.,
Teunissen Charlotte E.,
Broersen Laus M.,
Van Berckel Bart N.M.,
Scheltens Philip
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1238
Subject(s) - statistical parametric mapping , positron emission tomography , placebo , fluorodeoxyglucose , alzheimer's disease , pittsburgh compound b , medicine , dementia , nuclear medicine , analysis of variance , population , psychology , magnetic resonance imaging , pathology , disease , radiology , alternative medicine , environmental health
Background: Hypertension-induced microvascular injury is a major contributor to vascular dementia. However, no studies have ascertained the extent to which mild hypertension affects cerebral microcirculation and cognition. Using the American Heart Association’s 130/80 mmHg threshold for stage-1 hypertension, we investigated the impact of hypertension on neurovascular coupling and cognitive performance in postmenopausal women without overt disease. Methods: Baseline data was obtained from a two-year intervention trial in 146 postmenopausal women aged 6561 years who underwent a battery of 10 cognitive tests. Compliance of large and small systemic arteries was assessed with Cardiovascular Profiler. Transcranial Doppler Ultrasound was used to determine responsiveness of cerebral arteries to cognitive tests (neurovascular coupling). Central adiposity was assessed using Dual Energy X-ray Absorptiometry. Fasting blood lipids were also measured. Results: Of the 146 women, 54 were hypertensive (14161/7561 for SBP/DBP) and slightly older (6761 years) than the normotensives (6461 years, 11461/6461 for SBP/DBP). The hypertensive group had higher BMI, central adiposity and triglycerides and lower compliance of small (-33%) and large (-20%) arteries. Their neurovascular coupling was significantly lower during tests of processing speed (-31%) and cognitive flexibility (-26%). However, cognitive performance did not differ. SBP was negatively associated with neurovascular coupling during tests of processing speed (r1⁄4-0.332, p<0.001), cognitive flexibility (r1⁄4-0.294, p1⁄40.002) and overall cognition (r1⁄4-0.326, p1⁄40.001).Conclusions: Despite having similar cognitive performance, impaired cerebrovascular responsiveness was observed in stage-1 hypertensives compared with normotensives. Both blood pressure and central adiposity can contribute to this dysfunction. Preventive strategies to reduce risk factors are crucial for maintaining optimal cerebrovascular function.