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P1‐602: EXERCISE YOUR BRAIN NETWORKS TO PREVENT ALZHEIMER'S DISEASE
Author(s) -
Frutos Jaisalmer,
Cuesta Pablo,
Peral-Suarez Africa,
Cuadrado-Soto Esther,
Toraño Federico Ramirez,
Brown Belinda M.,
Fernández Ricardo Bruña,
Sanz David Lopez,
Delgado Losada Maria Luisa,
Rodríguez Rojo Inmaculada Concepción,
Barabash Ana,
Lopez Sobaler Ana Maria,
Serrano Rodriguez Juan Manuel,
Laws Simon M.,
Higes Ramon Lopez,
Maestu Fernando
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1207
Subject(s) - medicine , cluster (spacecraft) , dementia , apolipoprotein e , neuropathology , audiology , disease , resting state fmri , psychology , physical medicine and rehabilitation , physical therapy , neuroscience , computer science , programming language
community-dwelling healthy individuals aged 70–85 years. Total volume of activity at a moderate to vigorous intensity and timing of activity and sleep pattern were measured by 3 axial accelerometer throughout each 24-h period for 1 month. Participants also completed the morningness-eveningness questionnaire, which is a 19-item self-report scale with questions focusing on habitual waking and bed times. The association between daily activity, chronotype and risk of cognitive frailty was determined using a multiple logistic regression model. Results: Ageand sex-adjusted incidence rate of cognitive frailty was significantly greater in subjects with eveningness chronotype and low active thanmorningness and high active. These associations remained unchanged after adjustment for potential confounding factors (eveningness: odds ratio (OR)1⁄42.32, 95% confidence interval (CI)1⁄41.21–4.13 for cognitive frailty; Low active (<12min/day ofMVPA): OR1⁄42.69, 95%CI1⁄41.27–4.88 for cognitive frailty). Conclusions: In this cross-sectional study design, causation cannot be inferred. Nevertheless, we suggest that from the viewpoint of cognitive and physical health, older population should be encouraged to engage in lowandmoderate-intensity habitual physical activity, taking a duration> 12 min/day at a moderate intensity. Moreover, these results suggest that elderly with higher eveningness chronotype also have higher risks of cognitive frailty.