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P1‐537: ADIPOSITY IS RELATED TO VASCULAR AND VOLUMETRIC BRAIN OUTCOMES IN THE RUN DMC STUDY
Author(s) -
Gustafson Deborah R.,
Arnoldussen Ilse A.C.,
Leijsen Esther,
Leeuw Frank-Erik,
Kiliaan Amanda
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1142
Subject(s) - medicine , body mass index , white matter , adiponectin , adipokine , hyperintensity , leptin , brain size , dementia , diffusion mri , magnetic resonance imaging , overweight , waist , fractional anisotropy , cardiology , obesity , disease , radiology , insulin resistance
subjective cognitive performance. Those selected undergo baseline visit for (1) diagnosis (SCD/MCI), (2) collecting data feeding a dementia risk algorithm and (3) getting their personalised prevention action plan. At the subsequent visit, their risk estimates are disclosed and a personalised primary prevention advice given. Individuals with MCI are readily offered to enter studies and trials they may benefit from. The emotional impact of disclosure is measured at 1 and 6 weeks and 6 and 12 months post-disclosure. At 6-weeks, SCD participants are also offered to enter suitable prevention trials (Fig.1). Cost-benefit of this program will also be calculated using standard methods. Results: BBDPRC was presented in a press conference and 715 persons registered in the study’s webpage in 48 hours (w1,600, 8 months later): 53.2% of them were classified as a priori eligible (Fig.2) and w100 have undergone baseline visit (screening failure rate<9%). Of them, 22.4% have been diagnosed as MCI, 49.3% as SCD+ (fulfilling >3 SCD+ features) and 28.3% as SCD. More than half (58.2%) of these participants comply with eligibility criteria with ongoing studies at BBRC (Fig.3). Conclusions: We have established a web-based registry that is proving very useful to recruit SCD+ or MCI individuals, more than half of which are suited for secondary prevention interventions.