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P1‐517: SEX, RACE AND AGE DIFFERENCES IN PREVALENCE OF ALZHEIMER'S DISEASE AND RELATED DEMENTIA IN MEDICARE CLAIMS AND SURVEY DATA
Author(s) -
Zhu Yingying,
Chen Yi,
Crimmins Eileen M.,
Zissimopoulos Julie M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1122
Subject(s) - dementia , medicine , gerontology , logistic regression , disease , demographics , demography , prevalence , health and retirement study , population , test (biology) , cognition , cognitive test , psychiatry , environmental health , paleontology , pathology , sociology , biology
screening. However, the screening feasibility of MBI-C in AD population still need to be verified. Objective: To calculated the reliability and validity of MBI-C, as well as compared its sensitivity and specificity with NPI-Q to develop a new AD screening scale suitable for Chinese. Methods: MBI-C was translated into Chinese and back translated with the consent of the original author. Forty six patients with Alzheimer’s disease (AD) in the memory clinic of Xuanwu hospital and 50 gender and education matched controls were selected from community. All subjects were evaluated by the MBI-C, the neuropsychiatric inventory questionnaire (NPIQ), the mini-mental state examination (MMSE), the Montreal cognitive assessment (MoCA), the activity of daily life scale (ADL) and the clinical dementia rating scale (CDR). Among them, fifteen patients with AD were evaluated repeatedly after the interval of more than 24h, and eight patients with ADwere evaluated simultaneously by 2 evaluators. Results: The Chinese version of the MBI-C demonstrated great internal consistency reliability (Cronbach’a1⁄4 0.936), test-retest reliability (Linear correlation coefficient1⁄40.841), and inter-evaluator reliability (Linear correlation coefficient1⁄40.991). The optimal cutoff point of the MBI-C is 6/7 for identifying AD dementia against controls, with a good sensitivity (86.96%) and specificity (86.00%) better than NPI-Q (sensitivity76.09% and specificity76.00%). The Pearson correlation coefficients ranged from 0.702 to 0.831 showing a good content validity. Moreover, the Pearson correlation coefficients is 0.758 to reflect the criterion validity. Meanwhile, MBI-C can also distinguish the severity of AD dementia. Moreover, MBI-C scores were significantly negatively correlated with MMSE and MoCA scores (r1⁄4-0.641, P < 0.05;r1⁄4-0.623, P < 0.05), positively correlated with ADL (r1⁄40.742, P < 0.05). Conclusions: This study shows that the Chinese version of MBI-C has a high reliability and validity, as well as be more sensitive and specific for screening AD patients compared with NPI-Q. MBI-C is expected to be an effective tool for screening AD in Chinese.