P1‐484: DIABETES IN PRECLINICAL AD DOWNREGULATES ANXIETY AND RELATED AFFECT TASK FMRI ACTIVITY IN MIDLIFE, THEN POTENTIATES EMOTIONAL DYSFUNCTION IN LATE LIFE

observed in measures of language (B1⁄4.41, p<.03) and verbal fluency (B1⁄4.41, p<.03). We then stratified the sample according to disease stage (early vs. advanced) and evaluated the effects of education on cognition. Educational attainment showed positive effects on language in those early in the disease process, and preserved verbal fluency among those with advanced disease. Conclusions: These results indicate that cognitive reserve has a positive effect on cognition in patients with ALS, and these effects are most strongly associated with measures of language. The positive effects of cognitive reserve on cognitive functioning are in line with most literature; however, we expand upon these findings by illustrating the protective effects of education on language and communication.