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P1‐432: DIETARY INTAKE OF FLAVONOLS ASSOCIATED WITH LESS AD NEUROPATHOLOGY
Author(s) -
Holland Thomas M.,
Agarwal Puja,
Wang Yamin,
Schneider Julie A.,
Bennett David A.,
Booth Sarah,
Morris Martha Clare
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1037
Subject(s) - neuropathology , flavonols , myricetin , neurofibrillary tangle , medicine , dementia , cohort , cognitive decline , kaempferol , alzheimer's disease , neurotoxicity , endocrinology , physiology , gerontology , disease , quercetin , senile plaques , chemistry , antioxidant , toxicity , biochemistry
Background: In previous studies we observed protective associations of dietary intakes of flavonols with Alzheimer’s dementia and cognitive decline. In this study, we investigated the associations of total flavonol intake and its constituents (kaempferol, quercetin, myricetin, and isorhamnetin) to the burden of Alzheimer’s disease neuropathology in a large community-based cohort study.Methods: Dietary intakes of flavonols obtained through food frequency questionnaires pre-mortem were related to post-mortem brain measures of AD neuropathology among 468 deceased participants of the Rush Memory and Aging project (MAP). Neuropathological outcomes included global burden of AD neuropathology, average cortical amyloid load, neurofibrillary tangle density, NIA-Reagan score (likelihood of AD diagnosis), Braak stage (semiquantitative measure of neurofibrillary tangle spread and severity), and CERAD score (semiquantitative score of neuritic plaques). We used linear and logistic regression models to examine associations of tertiles of energy-adjusted intakes of flavonols with the neuropathologic outcomes. Results: In separate linear regression models adjusted for age, sex, and education (basic model), the highest tertile versus lowest tertile of total flavonol intake was significantly associated with a lower global AD pathology (b1⁄4 -0.31 SE 1⁄4 0.14, p value1⁄4 0.03), average amyloid burden (b1⁄4 -0.67, SE1⁄4 0.25, p1⁄4 0.008) and CERAD score (b1⁄4 -0.26, SE1⁄40.13, p1⁄4 0.04). In similar analyses of the individual flavonols, we observed statistically significant inverse associations with average amyloid burden in kaempferol (b1⁄4 -0.49, SE1⁄40.12, p1⁄40.05), quercetin (b1⁄4 -0.48, SE1⁄40.25, p1⁄40.05), and myricetin (b1⁄4 -0.54 SE1⁄40.25, p1⁄40.03). Dietary intake of isorhamnetin was inversely associated with global AD pathology (b1⁄4 -0.33, SE1⁄40.14, p1⁄40.02), neurofibrillary tangles (b1⁄4 -0.30, SE1⁄40.15, p1⁄40.05), NIA-Reagan score (b1⁄4 -0.19, SE1⁄40.08, p1⁄40.02), and CERAD score (b1⁄4 -0.27, SE1⁄40.13, p1⁄40.03). No associations were observed for Braak stage. Conclusions: Dietary flavonols may be associated with less Alzheimer’s disease neuropathology.