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P1‐431: VASCULAR MEDICAL TREATMENTS INFLUENCE THE ASSOCIATION BETWEEN VASCULAR BURDEN AND AMYLOID PATHOLOGY IN ASYMPTOMATIC INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASE
Author(s) -
Köbe Theresa,
Gonneaud Julie,
Binette Alexa Pichet,
Meyer Pierre-François,
McSweeney Melissa,
Rosa-Neto Pedro,
Breitner John C.S.,
Poirier Judes,
Villeneuve Sylvia
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1036
Subject(s) - blood pressure , medicine , pulse pressure , asymptomatic , dyslipidemia , cardiology , apolipoprotein e , endocrinology , disease
neurofibrillary tangle severity (Braak score) by using linear and logistic regression models among 179 deceased participants of the prospective Rush Memory and Aging Project. Multivariable models were adjusted for age at death, gender, education, APOE E4, body mass index, estimated glomerular filtration rate, and postmortem autopsy time. Results: The average age at death was 92 (SD 6) years, and 76% were women. The Spearman correlation coefficient of 1.25-dihydroxy vitamin D with 25-hydroxyvitamin D and vitamin D3 in the brain were 0.28 and 0.23, respectively. The correlation coefficient of 25-hydroxyvitamin D with vitamin D3 was 0.57. Higher concentration of 1.25-dihydroxy vitamin D and 25-hydroxyvitamin D in the brain were associated with the lower amyloid load. Compared to the brains of participants in the lowest 1.25-dihydroxy vitamin, participants in the medium and higher category had 0.02 and 0.38-unit lower amyloid load (b1⁄4-0.02 and b1⁄4-0.38, p for trend1⁄40.037) in the multivariable-adjusted model. For the 25-hydroxyvitamin D, these estimates were b1⁄4-0.16 and b1⁄40.34, p for trend1⁄40.032. The 1.25-dihydroxy vitamin D was also associated with a lower neuritic plaques severity (CERAD score). One standard deviation increase in 1.25-dihydroxy vitamin D was associated with a 25% lower risk of CERAD score (odds ratio1⁄40.75 p-value1⁄40.038). Vitamin D3 in the brain were not associated with Alzheimer’s disease neuropathology. Conclusions: Brain concentrations of 1.25-dihydroxy vitamin D and 25hydroxyvitamin D could have an impact on Alzheimer’s disease neuropathology by lowering the amyloid levels in the brain. However, further investigations will be required to establish the contribution of vitamin D on Alzheimer’s disease.