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P1‐424: AN RCT TO IDENTIFY BEST PRACTICES FOR DISCLOSURE OF AMYLOID IMAGING RESULTS IN MILD COGNITIVE IMPAIRMENT: THE ABIDE SIMULATION‐STUDY
Author(s) -
Fruijtier Agnetha D.,
Visser Leonie N.C.,
Van Maurik Ingrid S.,
Scheltens Philip,
Bouwman Femke H.,
Pijnenburg Yolande A.L.,
Ebenau Jarith,
Van Berckel Bart N.M.,
Smets Ellen M.,
Flier Wiesje M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1029
Subject(s) - vignette , randomized controlled trial , recall , anxiety , cognition , psychology , clinical psychology , medicine , psychiatry , social psychology , cognitive psychology
individuals could be consistently divided into caudo-rostral progression and amygdala arising progression categories by 1) expert analysis taking into account differences in density and distribution profiles of the semiquantitative LRP scores and 2) by statistical K-means cluster analysis.The LRP data was compared with the CERAD and Braak NFT scores, and APOEgenotypes. Results: Any LRP was found in 124 individuals (41%). 43 were classified as neocortical type, 41 as limbic, 19 as brainstem, 10 as amygdala-predominant, while 11 were non-classifiable, based on the DLB Consortium guidelines. Expert analysisindicated two distinct pathological profiles of progression, and K-means cluster analysis supported the classification of individuals into two clusters: 73 (59 %) subjects showed caudo-rostral progression and 39 (31 %) amygdala arising progression. Severe BraakNFT stage, high CERAD score andAPOE e4were significantly (p<0.001) associated with amygdala arising progression but not with caudo-rostral progression. Conclusions: Our data demonstrate two distinct LRP progression patterns in the very elderly population, and support previous hypotheses on LRP progression. The amygdala arising pattern was strongly associated with AD neuropathology and APOE e4, while the caudo-rostral pattern did not associate with these.