Premium
P1‐412: [ 18 F]FLORTAUCIPIR BINDING STRONGLY CORRELATES TO COGNITION ACROSS THE CLINICAL ALZHEIMER'S DISEASE CONTINUUM, INDEPENDENTLY OF CSF TAU
Author(s) -
Wolters Emma E.,
Ossenkoppele Rik,
Verfaillie Sander C.J.,
Coomans Emma,
Timmers Tessa,
Visser Denise,
Tuncel Hayel,
Windhorst Albert D.,
Boellaard Ronald,
Flier Wiesje M.,
Teunissen Charlotte E.,
Scheltens Philip,
Van Berckel Bart N.M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1017
Subject(s) - medicine , cognition , cerebrospinal fluid , binding potential , cognitive decline , psychology , linear regression , standardized uptake value , effects of sleep deprivation on cognitive performance , statistical parametric mapping , alzheimer's disease , nuclear medicine , pathology , oncology , positron emission tomography , neuroscience , disease , magnetic resonance imaging , dementia , receptor , mathematics , radiology , statistics
Flortaucipir trait weights and MTL tau SUVR, likely due to the sample having fewer subjects with diffuse tau than diffuse amyloid. The amyloid trait (Fig.3) was heavily represented in the DMN, consistent with previous literature in later stage subjects. The tau trait was heavily represented in the visual cortex (Fig.5), likely driven by subjects exhibiting diffuse deposition given that these subjects drove the trait’s group effect and correlation with MTL tau (Fig4A-B). The proposed method was able to capture covarying processes between PET and FC changes in AD. Results suggest a prominent role of amyloid on functional connectivity in pre-symptomatic subjects.