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P1‐410: WORSENING FUNCTIONAL CONNECTIVITY WITHIN DEFAULT MODE NETWORK IS ASSOCIATED WITH HIGHER AV‐1451 PET UPTAKE IN THE MEDIAL TEMPORAL LOBE
Author(s) -
Scott David,
Bracoud Luc,
Adamczuk Kate,
Suhy Joyce
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1015
Subject(s) - default mode network , temporal lobe , functional connectivity , neuroscience , tau pathology , voxel , resting state fmri , nuclear medicine , cardiology , psychology , medicine , alzheimer's disease , disease , radiology , epilepsy
(Figure 2). The ADNI replication analysis revealed patterns of FBB-CBF correlations that were similar to patterns observed in the USC discovery cohort (Figure 3), which were more prominent in cognitively normal participants. No regions showed significant FTP-CBF correlations using the discovery results as a mask. However, exploratory analyses demonstrated strong FTP-CBF correlations in participants with greater clinical symptoms, in regions known to have early tau pathology, such as entorhinal cortex and inferior temporal gyrus (Figure 4). Conclusions: Our results support previous evidence of negative associations between amyloid binding and CBF for the FBB amyloid tracer and broaden these findings to a clinically meaningful pattern of tau binding. Future, longitudinal studies are needed to explore the likely complex temporal relationship between AD pathology and CBF. P1-410 WORSENING FUNCTIONAL CONNECTIVITY WITHIN DEFAULT MODE NETWORK ISASSOCIATEDWITHHIGHER AV-1451 PET UPTAKE IN THE MEDIAL TEMPORAL LOBE David Scott, Luc Bracoud, Kate Adamczuk, Joyce Suhy, and the Alzheimer’s Disease Neuroimaging Initiative, Bioclinica, Inc., Newark, CA, USA; Bioclinica, Inc., Lyon, France. Contact e-mail: david.scott@ bioclinica.com