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P1‐400: IMPACT OF REFERENCE REGION USED TO QUANTIFY AMYLOID BURDEN ON INTERPRETING THE RELATIONSHIP BETWEEN AMYLOID BURDEN AND GENETIC RISK FACTORS OF AD
Author(s) -
Wang Qi,
Del-Aguila Jorge L.,
Cruchaga Carlos,
Reiman Eric M.,
Su Yi
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1005
Subject(s) - white matter , neuroimaging , amyloid (mycology) , medicine , biology , pathology , neuroscience , magnetic resonance imaging , radiology
(worry) and significant phenotype-by-genotype (APOE ε4) interactions on total cortical volume (P1⁄40.001) and bilateral surface area (RH: P1⁄40.001; LH: P1⁄40.003) in SCD. Post hoc comparisons showed that SCD with worry had significantly decreased cortical volume and surface area compared to no-worry SCD in APOE ε4 carriers (P1⁄40.001). While in ε4 non-carriers, there was no significant differences between groups (P1⁄40.398) (Fig.A). Intriguingly, we further observed reduced cortical volume and surface area in ε4 carriers than non-carriers in worry SCD, while increased volume and area in ε4 carriers than non-carriers in no-worry SCD. Conclusions: The reported worry of memory and APOE ε4 allele have synergistic effects on cortical reduction in SCD, providing new insights into the biological mechanism of AD-related phenotype and genotype risk factors in SCD.