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P1‐396: APOE ‐ε4 RISK VARIANT FOR ALZHEIMER'S DISEASE IMPACTS ON BRAIN STRUCTURAL NETWORKS IN COGNITIVELY UNIMPAIRED MIDDLE‐AGED INDIVIDUALS
Author(s) -
Cacciaglia Raffaele,
Molinuevo Jose Luis,
Falcón Carles,
Sánchez-Benavides Gonzalo,
Brugulat-Serrat Anna,
Gramunt Nina,
Gispert Juan Domingo
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.1001
Subject(s) - apolipoprotein e , white matter , psychology , allele , audiology , medicine , disease , neuroscience , biology , genetics , magnetic resonance imaging , gene , radiology
(N1⁄4233), PET-Ab positive patients were 50.2% (N1⁄4235). In univariable logistic regression analysis, age (OR 1.022, p 1⁄4 0.040), sex (female compared with male, OR 1.841, p 1⁄4 0.002), and presence of APOE ε4 (OR 5.390, p< 0.001) were associated with PETAb positivity. In multivariable logistic regression analysis, age (OR 1.106, p< 0.001) and presence of APOE ε4 (OR 11.483, p< 0.001) was associated with PET-A b positivity. Conclusions: Age and APOE ε4 genotype may provide a useful predictive model of PET-A b positivity. Based on this result, it is cost-effective to carry out additional amyloid PET if patients are elderly person and have an APOE ε4 genotype.