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P1‐061: HIGH FREQUENCY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION COMBINED WITH COGNITIVE TRAINING IMPROVED COGNITIVE FUNCTION AND CORTICAL METABOLIC RATIOS IN ALZHEIMER'S DISEASE
Author(s) -
Zhang Fengxia
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.086
Subject(s) - transcranial magnetic stimulation , creatine , medicine , neuropsychology , choline , cognition , psychology , stimulation , psychiatry
monotherapy group and 16 patients in combination therapy group. The univariate analysis showed that the age, gender, years of education, the prevalence of hypertension, diabetes mellitus, APOEε4 carrier and baseline MMSE score had no significant difference between the two groups(P>0.05). The multiple linear regression analysis showed that the endpoint to baseline change of ADAS-cog in combination therapy group was less than that in monotherapy group(b1⁄4-3.965,P1⁄40.021), while there were no difference of the endpoint to baseline change of MMSE(b1⁄40.619, P1⁄40.497),ADCS-ADL(b1⁄41.675,P1⁄40.541)and NPI(b1⁄45.478,P1⁄40.255)between the two groups. The multivariate Logistic regression analysis showed that the endpoint CIBIC-plus had no difference between the two groups OR1⁄40.866 95% CI: [0.082,9.179],P1⁄40.905. Conclusions: Over the 48-week treatment period, NBP combination with donepezil was effective for delaying cognitive decline in patients with mild to moderate AD.