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P1‐029: CHANGE IN BLOOD PRESSURE AND THE RISK OF DEMENTIA OVER 26 YEARS: THE ROTTERDAM STUDY
Author(s) -
Ma Yuan,
Wolters Frank J.,
Chibnik Lori B.,
Licher Silvan,
Ikram M. Arfan,
Hofman Albert,
Ikram M. Kamran
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.054
Subject(s) - dementia , rotterdam study , hazard ratio , medicine , confidence interval , prospective cohort study , cohort study , blood pressure , cohort , demography , cognitive decline , gerontology , disease , sociology
frequency of MCI differed by group at last assessment, but MMSE, selfand informant-reported memory problems, and WAIS-R Digit Symbol did not (Table 2). Conclusions: These results suggest concurrent NFT and AB pathophysiologies contribute to measurable cognitive decline prior to clinical impairment, and support the ATN framework using neuroimaging markers. The PACC-3 score may be sensitive to early pathophysiological changes occurring during preclinical AD.