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P1‐028: POLYGENIC RISK SCORE DISTRIBUTIONS OF ALZHEIMER'S DISEASE WITHIN DIFFERENT POPULATIONS
Author(s) -
Bellou Eftychia,
Leonenko Ganna,
Daunt Paula,
Oshota Olusegun,
Gibson Alex,
Pither Richard,
Sims Rebecca,
Williams Julie,
Escott-Price Valentina
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.053
Subject(s) - linkage disequilibrium , cohort , single nucleotide polymorphism , biology , disease , allele , genetic association , allele frequency , genetics , demography , medicine , gene , genotype , sociology
frequency of MCI differed by group at last assessment, but MMSE, selfand informant-reported memory problems, and WAIS-R Digit Symbol did not (Table 2). Conclusions: These results suggest concurrent NFT and AB pathophysiologies contribute to measurable cognitive decline prior to clinical impairment, and support the ATN framework using neuroimaging markers. The PACC-3 score may be sensitive to early pathophysiological changes occurring during preclinical AD.