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P1‐014: CEREBROVASCULAR, COGNITIVE AND GLYCAEMIC BENEFITS OF LONG‐TERM RESVERATROL SUPPLEMENTATION IN POSTMENOPAUSAL WOMEN
Author(s) -
Thaung Zaw Jay Jay,
Howe Peter RC.,
Evans Hamish M.,
Wong Rachel HX.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.039
Subject(s) - effects of sleep deprivation on cognitive performance , medicine , transcranial doppler , cognition , verbal memory , cognitive decline , placebo , cognitive flexibility , estrogen , blood pressure , dementia , psychiatry , alternative medicine , disease , pathology
mellitus, physical activity, depression and anxiety. Core AD biomarkers (Ab42, t-tau and p-tau) were measured in cerebrospinal fluid (CSF) using Elecsys and subjects were categorized according to whether or not they were amyloid (A) positive (CSF Ab42 < 1098 pg/mL), tau (T) positive (p-tau > 19.2 pg/mL) and neurodegeneration (N) positive (t-tau > 242 pg/mL). We used logistic regression analyses to test whether the risk factors predict CSF biomarker positivity, adjusted by the effect of age, gender, years of education and APOE-ε4 status. Results: We studied 257 participants, with a mean age of 60.7 years, 64.5% were female, 40.1% APOE-ε4carriers and 29.6% were A+, 26.1% T+ and 23.3% N+. Physical activity was associated with reduced risk of amyloidosis; 46.7% of physically inactive individuals were A+ vs 25.9% of physically active subjects (P 1⁄4 0.014). No significant associations were found regarding the other risk factors. Conclusions: The findings of this exploratory study suggest that physical activity is associated with lower amyloid burden. Future studies in larger, longitudinal and independent populations are needed to further confirm these results.