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P1‐008: SEX‐SPECIFIC ASSOCIATIONS OF CEREBROSPINAL FLUID TAU AND NEUROGRANIN CONCENTRATIONS WITH ALZHEIMER'S NEUROIMAGING SIGNATURES
Author(s) -
Moore Elizabeth E.,
Kresge Hailey A.,
Khan Omair A.,
Bown Corey W.,
Liu Dandan,
Pechman Kimberly R.,
Acosta Lealani Mae Y.,
Bell Susan P.,
Shashikumar Niranjana,
Ahmed Humza A.,
Turchan Maxim,
Landman Bennett A.,
Blennow Kaj,
Zetterberg Henrik,
Hohman Timothy J.,
Jefferson Angela L.,
Gifford Katherine A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.033
Subject(s) - neurogranin , neurodegeneration , cerebrospinal fluid , neuropathology , biomarker , neuroimaging , magnetic resonance imaging , neuroscience , medicine , alzheimer's disease neuroimaging initiative , psychology , pathology , dementia , atrophy , oncology , disease , chemistry , radiology , protein kinase c , enzyme , biochemistry
adjusted for age, gender, education, and ApoE4 status, we found that race significantly modified the relationship between total tau, phospho-tau and Trails b, a marker of executive function. Small differences in tau correlated with poorer cognition in AAs when compared to Whites (Figure 1, 2, and 3). Conclusions: In a cohort of middle-aged individuals with a parental history of AD, AAs had higher central BP and lower tau burden than Whites, and may be more sensitive to small changes in tau as evidenced by worse cognition.