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P1‐005: DIFFERENT DIAGNOSIS GUIDELINES ON THE ALZHEIMER'S DISEASE CONTINUUM
Author(s) -
Bieger Andrei,
Zimmer Eduardo R.,
Benedet Andrea Lessa,
Pascoal Tharick A.,
Brum Wagner Scheeren,
Souza Diogo O.,
Rosa-Neto Pedro
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.030
Subject(s) - alzheimer's disease neuroimaging initiative , neuropsychology , medicine , disease , alzheimer's disease , psychiatry , cognition
decreased percentage of resident microglia and increased percentage of infiltrated macrophages were observed when compared with ND-fed rats (p<0.05; Figure 1). In contrast, the level of Ab/ APP and BACE-1 expression was not different between both dietary groups at all time periods. Conclusions: HFD consumption alters gut microbiota prior to metabolic disturbance, leading to brain oxidative stress, synaptic dysplasticity, microglia hyperactivation, and cognitive decline without increasing Alzheimer’s markers in obese-insulin resistant rats. Therefore, the improvement of gut dysbiosis should be a therapeutic target to prevent cognitive decline in obese people.
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