Premium
Biopsychosocial frailty and the risk of incident dementia: The Italian longitudinal study on aging
Author(s) -
Solfrizzi Vincenzo,
Scafato Emanuele,
Lozupone Madia,
Seripa Davide,
Schilardi Andrea,
Custodero Carlo,
Sardone Rodolfo,
Galluzzo Lucia,
Gandin Claudia,
Baldereschi Marzia,
Di Carlo Antonio,
Inzitari Domenico,
Giannelli Gianluigi,
Daniele Antonio,
Sabbà Carlo,
Logroscino Giancarlo,
Panza Francesco
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.04.013
Subject(s) - dementia , biopsychosocial model , psychosocial , hazard ratio , gerontology , medicine , longitudinal study , cohort , confidence interval , cohort study , population , psychology , psychiatry , disease , environmental health , pathology
Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial domains/phenotypes. We operationalized a new biopsychosocial frailty (BF) construct, estimating its impact on the risk of incident dementia and its subtypes. Methods In 2171 older individuals from the population‐based Italian Longitudinal Study on Aging (ILSA), we identified by latent class procedures the BF construct as the physical frail status plus at least one of the two items of the 30‐item Geriatric Depression Scale impaired (items 3/10). Results Over a 3.5‐year follow‐up, participants with BF showed an increased risk of overall dementia (hazard ratio [HR]: 2.16, 95% confidence interval [CI]:1.07‐4.37), particularly vascular dementia (VaD) (HR: 3.21, 95% CI: 1.05‐9.75). Similarly, over a 7‐year follow‐up, an increased risk of overall dementia (HR: 1.84, 95% CI: 1.06‐3.20), particularly VaD (HR: 2.53, 95% CI: 1.08‐5.91), was also observed. Discussion In a large cohort of Italian older individuals without cognitive impairment at baseline, a BF model was a short‐ and long‐term predictor of overall dementia, particularly VaD.