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Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
Author(s) -
Lowe Val J.,
Lundt Emily S.,
Albertson Sabrina M.,
Przybelski Scott A.,
Senjem Matthew L.,
Parisi Joseph E.,
Kantarci Kejal,
Boeve Bradley,
Jones David T.,
Knopman David,
Jack Clifford R.,
Dickson Dennis W.,
Petersen Ronald C.,
Murray Melissa E.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.03.016
Subject(s) - neuroimaging , tauopathy , pittsburgh compound b , pathology , senile plaques , alzheimer's disease , medicine , neurofibrillary tangle , positron emission tomography , autopsy , pathophysiology , neuropathology , disease , alzheimer's disease neuroimaging initiative , psychology , nuclear medicine , neurodegeneration , psychiatry
Neuroimaging biomarkers are important for early diagnosis of Alzheimer's disease, and comparing multimodality neuroimaging to autopsy data is essential. Methods We compared the pathologic findings from a prospective autopsy cohort (n = 100) to Pittsburgh compound B PET (PiB‐PET), 18 F‐fluorodeoxyglucose PET (FDG‐PET), and MRI. Correlations between neuroimaging biomarkers and neuropathologic schemes were assessed. Results PiB‐PET showed strong correlations with Thal amyloid phase and Consortium to Establish a Registry for Alzheimer's Disease score and categorized 44% of Thal phase 1 participants as positive. FDG‐PET and MRI correlated modestly with Braak tangle stage in Alzheimer's type pathology. A subset of participants with “none” or “sparse” neuritic plaque scores had elevated PiB‐PET signal due to diffuse amyloid plaque. Participants with findings characterized as “suspected non‐Alzheimer's pathophysiology” represented 15% of the group. Discussion PiB‐PET is associated with Alzheimer's disease, neuritic plaques, and diffuse plaques. FDG‐PET and MRI have modest correlation with neuropathologic schemes. Participants with findings characterized as suspected non‐Alzheimer's pathophysiology most commonly had primary age‐related tauopathy.