Premium
Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study
Author(s) -
Verghese Joe,
Wang Cuiling,
Bennett David A.,
Lipton Richard B.,
Katz Mindy J.,
Ayers Emmeline
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.03.011
Subject(s) - dementia , clinical dementia rating , cognition , psychology , cognitive decline , cohort , psychiatry , hazard ratio , medicine , disease , physical medicine and rehabilitation , physical therapy , clinical psychology , confidence interval
To report clinical predictors of transition to dementia in motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by cognitive complaints and slow gait. Methods We examined if cognitive or motoric impairments predicted transition to dementia in 610 older adults with MCR from three cohorts. Association of cognitive (logical memory, clinical dementia rating, cognitive complaint severity, and Mini–Mental State Examination) and motoric factors (gait velocity) with dementia risk was computed using Cox models. Results There were 156 incident dementias (134 Alzheimer's disease). In the pooled sample, logical memory (adjusted hazard ratio [aHR] 0.91), cognitive complaint severity (aHR 1.53), and Mini–Mental State Examination (aHR 0.75) predicted transition of MCR to dementia. Clinical dementia rating score ≥0.5 predicted dementia (aHR 3.18) in one cohort. Gait velocity did not predict dementia. Discussion While MCR is a motoric‐based predementia syndrome, severity of cognitive but not motoric impairments predicts conversion to dementia.