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Brain atrophy in primary age‐related tauopathy is linked to transactive response DNA‐binding protein of 43 kDa
Author(s) -
Josephs Keith A.,
Murray Melissa E.,
Tosakulwong Nirubol,
Weigand Stephen D.,
Knopman David S.,
Petersen Ronald C.,
Jack Clifford R.,
Whitwell Jennifer L.,
Dickson Dennis W.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.03.003
Subject(s) - atrophy , tauopathy , hippocampal formation , neuroscience , entorhinal cortex , hippocampus , amygdala , pathology , psychology , medicine , biology , disease , neurodegeneration
Primary age‐related tauopathy (PART) is characterized by the presence of neurofibrillary tangles and absent‐minimal β‐amyloid deposition. Transactive response DNA‐binding protein of 43 kDa (TDP‐43), a third protein, has recently garnished a lot of attention in Alzheimer's disease where it is associated with memory loss and amygdala and hippocampal atrophy. We aimed to determine whether TDP‐43 is associated with brain atrophy in PART. Methods We assessed the frequency of TDP‐43 in PART and performed voxel‐level analysis in SPM12, as well as region‐of‐interest analysis using linear regression modeling, controlling for variables of interest, to assess for associations between TDP‐43 and brain atrophy. Results Of 116 PART cases, 31 (26.7%) had TDP‐43. The presence of TDP‐43 was associated with significantly greater amygdala, hippocampal, and anterior temporal atrophy in both the region‐of‐interest and the voxel level analyses. Discussion TDP‐43 is associated with greater brain atrophy in PART.