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Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study
Author(s) -
Lleó Alberto,
Alcolea Daniel,
MartínezLage Pablo,
Scheltens Philip,
Parnetti Lucilla,
Poirier Judes,
Simonsen Anja H.,
Verbeek Marcel M.,
RosaNeto Pedro,
Slot Rosalinde E.R.,
Tainta Mikel,
Izaguirre Andrea,
Reijs Babette L.R.,
Farotti Lucia,
Tsolaki Magda,
Vandenbergue Rik,
FreundLevi Yvonne,
Verhey Frans R.J.,
Clarimón Jordi,
Fortea Juan,
Frolich Lutz,
Santana Isabel,
Molinuevo José Luis,
Lehmann Sylvain,
Visser Pieter J.,
Teunissen Charlotte E.,
Zetterberg Henrik,
Blennow Kaj
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.01.015
Subject(s) - cerebrospinal fluid , biomarker , tau protein , medicine , dementia , alzheimer's disease , oncology , gastroenterology , psychology , disease , pathology , biology , biochemistry
Within‐person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild cognitive impairment (n = 128), and AD dementia (n = 110), and a group of cognitively unimpaired subjects (n = 154) were also included. We measured baseline and follow‐up CSF levels of total tau (t‐tau), phosphorylated tau (p‐tau), YKL‐40, and neurofilament light (NfL). Median CSF sampling interval was 2.1 years. Results CSF levels of t‐tau, p‐tau, NfL, and YKL‐40 were 2% higher per each year of baseline age in controls ( P <.001). In AD, t‐tau levels were 1% lower ( P <.001) and p‐tau levels did not change per each year of baseline age. Longitudinally, only NfL ( P <.001) and YKL‐40 ( P <.02) increased during the study period. Discussion All four CSF biomarkers increase with age, but this effect deviates in AD for t‐tau and p‐tau.