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A randomized clinical trial to evaluate home‐based assessment of people over 75 years old
Author(s) -
Sano Mary,
Zhu Carolyn W.,
Kaye Jeffrey,
Mundt James C.,
Hayes Tamara L.,
Ferris Steven,
Thomas Ronald G.,
Sun ChungKai,
Jiang Yanxin,
Donohue Michael C.,
Schneider Lon S.,
Egelko Susan,
Aisen Paul S.,
Feldman Howard H.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.01.007
Subject(s) - randomized controlled trial , medicine , gerontology , psychology
There is an unmet need for effective methods for conducting dementia prevention trials. Methods Home‐based assessment study compared feasibility and efficiency, ability to capture change over time using in‐home instruments, and ability to predict cognitive conversion using predefined triggers in a randomized clinical trial in (1) mail‐in questionnaire/live telephone interviews, (2) automated telephone/interactive voice recognition, and (3) internet‐based computer Kiosk technologies. Primary endpoint was defined as cognitive conversion. Results Analysis followed a modified intent‐to‐treat principle. Dropout rates were low and similar across technologies but participants in Kiosk were more likely to dropout earlier. Staff resources needed were higher in Kiosk. In‐home instruments distinguished conversion and stable groups. Cognitively stable group showed improvement in cognitive measures. Triggering was associated with higher likelihood of conversion but statistically significant only in mail‐in questionnaire/live telephone interviews. Discussion Relatively low efficiency of internet‐based assessment compared with testing by live‐assessors has implications for internet‐based recruitment and assessment efforts currently proposed for diverse populations.