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A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
Author(s) -
Fortier Mélanie,
Castellano ChristianAlexandre,
Croteau Etienne,
Langlois Francis,
Bocti Christian,
StPierre Valérie,
Vandenberghe Camille,
Bernier Michaël,
Roy Maggie,
Descoteaux Maxime,
Whittingstall Kevin,
Lepage Martin,
Turcotte Éric E.,
Fulop Tamas,
Cunnane Stephen C.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.12.017
Subject(s) - ketone bodies , cognition , ketogenic diet , placebo , effects of sleep deprivation on cognitive performance , executive functions , positron emission tomography , medicine , psychology , neuroscience , metabolism , epilepsy , pathology , alternative medicine
Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Methods Fifty‐two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later. Results Brain ketone metabolism increased by 230% for subjects on the kMCT ( P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy‐five percent of participants completed the intervention. Discussion A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI.