Premium
Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)
Author(s) -
Ramirez Aguilar Laura,
AcostaUribe Juliana,
Giraldo Margarita M.,
Moreno Sonia,
Baena Ana,
Alzate Diana,
Cuastumal Rosario,
Aguillón David,
Madrigal Lucía,
Saldarriaga Amanda,
Navarro Alexander,
Garcia Gloria P.,
AguirreAcevedo Daniel C.,
Geier Ethan G.,
Cochran J. Nicholas,
Quiroz Yakeel T.,
Myers Richard M.,
Yokoyama Jennifer S.,
Kosik Kenneth S.,
Lopera Francisco
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.12.010
Subject(s) - genetics , missense mutation , psen1 , population , dementia , haplotype , biology , founder effect , mutation , disease , medicine , alzheimer's disease , genotype , gene , presenilin , environmental health
A small percentage of Alzheimer's disease (AD) cases are caused by genetic mutations with autosomal dominant inheritance. We report a family with a novel variant in PSEN1. Methods We performed clinical and genetic evaluation of 93 related individuals from a Colombian admixed population. 31 individuals had whole‐genome sequencing. Results Genetic analysis revealed a missense variant in PSEN1 (NM_000021.3: c.1247T>C p.Ile416Thr), which originated on an African haplotype and segregated with AD logarithm of the odds score of 6. Their clinical phenotype is similar to sporadic AD except for earlier age at onset: the mean age at onset for mild cognitive impairment was 47.6 years (standard deviation 5.83) and for dementia 51.6 years (standard deviation 5.03). Discussion Ile416Thr is a novel pathogenic variant that causes AD in the sixth decade of life. The history of the region that included slave importation and admixtures within a confined geographic locale represents a “mini‐population bottleneck” and subsequent emergence of a rare dominant mutation.