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Incidence of dementia after age 90 in a multiracial cohort
Author(s) -
Gilsanz Paola,
Corrada Maria M.,
Kawas Claudia H.,
Mayeda Elizabeth Rose,
Glymour M. Maria,
Quesenberry Charles P.,
Lee Catherine,
Whitmer Rachel A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.12.006
Subject(s) - dementia , medicine , demography , incidence (geometry) , ethnic group , cohort , demographics , gerontology , proportional hazards model , disease , physics , sociology , anthropology , optics
Little is known about dementia incidence in diverse populations of oldest‐old, the age group with highest dementia incidence. Methods Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity‐specific age‐adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late‐life. Results Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person‐years), followed by whites (96.9/1000 person‐years), Latinos (105.8/1000 person‐years), and blacks (121.5/1000 person‐years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities. Discussion Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude.